Factors Predicting Successful Sperm Retrieval in Men with Non-Obstructive Azoospermia: A Single Center Study
SIU Academy®. Safar O. 11/12/21; 342117; UP-08.05 Topic: Male Infertility (including varicocele, etc)
Dr. Omar Safar
Dr. Omar Safar
Contributions
Abstract
Factors Predicting Successful Sperm Retrieval in Men with Non-Obstructive Azoospermia: A Single Center Study

Topic: Infertility

Applicant 1: Omar, Applicant 2: Raed, Applicant 3: Adel, Applicant 4: Iman, Applicant 5: Ahmed, Applicant 6: Abdulkareem

Applicant 1: Safar, Applicant 2: Alwadai, Applicant 3: Elatreisy, Applicant 4: Sadri, Applicant 5: Ibrahim, Applicant 6: Aljubran

Applicant 1: Armed Forces Hospital Southern Region, Applicant 2: Armed Forces Hospital Southern Region, Applicant 3: Armed Forces Hospital Southern Region, Applicant 4: McGill University Health Center, Applicant 5: McGill University Health Center, Applicant 6: Armed Forces Hospital Southern Region

Applicant 1: Saudi Arabia, Applicant 2: Saudi Arabia, Applicant 3: Saudi Arabia, Applicant 4: Canada, Applicant 5: Canada, Applicant 6: Saudi Arabia

Applicant 1: Presenting Author, Applicant 2: Author/Co-Author, Applicant 3: Author/Co-Author, Applicant 4: Author/Co-Author, Applicant 5: Author/Co-Author, Applicant 6: Author/Co-Author

Introduction and Objectives:

Successful recovery of spermatozoa is reported in almost half of cases of non-obstructive azoospermia (NOA). Thus, the prediction of patients with a high likelihood of achieving successful spermatozoa recovery is essential in counseling infertile couples.

Materials and Methods:

A retrospective study was conducted, including patients with non-obstructive azoospermia from 1st January 2018 to 30th May 2019. The cohort was subdivided into two groups, group one (negative sperm retrieval) and group two (positive sperm retrieval). Johnsen\'s score was determined for each testicular biopsy. 

Results:

The study included 108 patients. Their age ranged between 22 and 75 years with a mean±SD of 36.8±10 years. The rate of successful sperm retrieval was 47.2%. group one included 57 patients (52.8%), their age was 33.98 ± 6.18 and group two included 51 patients (47.2%), their age was 40.04 ± 12.22 (p-value =0.008).
FSH was significantly higher in group one (18.55 ± 13) compared to (7.97 ± 7.11) for group two with a p-value <0.004. Similarly, LH was significantly higher in group one (11.4 ± 7.45) compared to (5.9 ± 4.4) in group two patients with a p-value <0.001. Multivariate logistic regression analysis revealed that age and FSH were significantly associated with the sperm retrieval outcome in men with NOA. Among the 51 cases with successful sperm extraction, pregnancy happened in 13.7%; 28.6% delivered an alive baby.

Conclusion:

The age of the patients and serum FSH level are independent predictors of successful sperm retrieval for men with non-obstructive azoospermia.
Testicular histopathology is not a predictor for successful sperm retrieval in men with NOA; however, hypo-spermatogenesis has the best prognosis.

Factors Predicting Successful Sperm Retrieval in Men with Non-Obstructive Azoospermia: A Single Center Study

Topic: Infertility

Applicant 1: Omar, Applicant 2: Raed, Applicant 3: Adel, Applicant 4: Iman, Applicant 5: Ahmed, Applicant 6: Abdulkareem

Applicant 1: Safar, Applicant 2: Alwadai, Applicant 3: Elatreisy, Applicant 4: Sadri, Applicant 5: Ibrahim, Applicant 6: Aljubran

Applicant 1: Armed Forces Hospital Southern Region, Applicant 2: Armed Forces Hospital Southern Region, Applicant 3: Armed Forces Hospital Southern Region, Applicant 4: McGill University Health Center, Applicant 5: McGill University Health Center, Applicant 6: Armed Forces Hospital Southern Region

Applicant 1: Saudi Arabia, Applicant 2: Saudi Arabia, Applicant 3: Saudi Arabia, Applicant 4: Canada, Applicant 5: Canada, Applicant 6: Saudi Arabia

Applicant 1: Presenting Author, Applicant 2: Author/Co-Author, Applicant 3: Author/Co-Author, Applicant 4: Author/Co-Author, Applicant 5: Author/Co-Author, Applicant 6: Author/Co-Author

Introduction and Objectives:

Successful recovery of spermatozoa is reported in almost half of cases of non-obstructive azoospermia (NOA). Thus, the prediction of patients with a high likelihood of achieving successful spermatozoa recovery is essential in counseling infertile couples.

Materials and Methods:

A retrospective study was conducted, including patients with non-obstructive azoospermia from 1st January 2018 to 30th May 2019. The cohort was subdivided into two groups, group one (negative sperm retrieval) and group two (positive sperm retrieval). Johnsen\'s score was determined for each testicular biopsy. 

Results:

The study included 108 patients. Their age ranged between 22 and 75 years with a mean±SD of 36.8±10 years. The rate of successful sperm retrieval was 47.2%. group one included 57 patients (52.8%), their age was 33.98 ± 6.18 and group two included 51 patients (47.2%), their age was 40.04 ± 12.22 (p-value =0.008).
FSH was significantly higher in group one (18.55 ± 13) compared to (7.97 ± 7.11) for group two with a p-value <0.004. Similarly, LH was significantly higher in group one (11.4 ± 7.45) compared to (5.9 ± 4.4) in group two patients with a p-value <0.001. Multivariate logistic regression analysis revealed that age and FSH were significantly associated with the sperm retrieval outcome in men with NOA. Among the 51 cases with successful sperm extraction, pregnancy happened in 13.7%; 28.6% delivered an alive baby.

Conclusion:

The age of the patients and serum FSH level are independent predictors of successful sperm retrieval for men with non-obstructive azoospermia.
Testicular histopathology is not a predictor for successful sperm retrieval in men with NOA; however, hypo-spermatogenesis has the best prognosis.

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