Near Infrared Radiation in Diagnosis of Prostate Cancer: Preliminary Results
SIU Academy®. Khuskivadze A. 09/09/13; 32273; MP-05.16 Topic: Research
Dr. Alexandre Khuskivadze
Dr. Alexandre Khuskivadze
Login now to access Regular content available to all registered users.

To have an exclusive access to the entire content available on SIU Academy, become an SIU Member here.

You may also access SIU content "anytime, anywhere" with the FREE SIU ACADEMY App for iOS and Android.
Abstract
Discussion Forum (0)
Rate & Comment (0)
Near Infrared Radiation in Diagnosis of Prostate Cancer: Preliminary
Results

Introduction and Objectives: The goal of the present study was to
investigate the possibility of usage of near infrared radiation (NIR) in
the diagnosis of prostate cancer. Our current effort aims at developing
in vivo simple and cost-effective technology for visualization of
prostate cancer outgrowth at its early stage of development using NIR.

Materials and Methods: We present 10 cases in which radical
prostatectomy was performed. The pre-operative diagnosis of prostate
cancer was based on DRE, PSA, TRUS-B, bone scan and pelvic CT. Pathology
T1N0M0 was revealed in 4 cases, T2aN0M0 in 3 cases, and T2bN0M0 in 3
cases. After radical prostatectomy, the whole prostate was investigated
in near infrared radiation (NIR) and was compared to the respective
pathology reports. Prostates removed after the surgery were radiated
with 40 mw light emitted diode (LED) with the wavelength 850 nm- beyond
of the visible spectrum. Investigated material was placed between LED
and CCD camera in darkness, to avoid influence of any optical noise. The
images were obtained via a charge-coupled device (CCD) camera with the
resolution of up to 2 MP sensors and with the frame rates of up to 15
frames per second. CCD camera was connected to PC via USP port. The
images were then compared to the focused histopathological study.

Results: We have investigated penetration of NIR through the prostate
tissue. It was shown that NIR of 850 nm has highest penetration.
Infrared image of noncancerous prostate represents picture with
approximately even brightness. However obtained near-infrared images of
the cancerous outgrowths of the prostate revealed dense and dark foci,
which proved to be malignancy on pathology (adenocarcinoma, Gleason
score 6[3+3] in 7 cases and adenocarcinoma, Gleason score 7[3+4] in 3
cases). At brighter areas the pathology report did not reveal the
presence of malignant cells. Obtained IR images give opportunity to
distinguish prostate cancerous outgrowth with the dimensions of several
millimeter.

Conclusion: In all cases, suspected areas on NIR images were confirmed
as malignancy on pathology. These findings are expected to have impact
on more accurate diagnosis of prostate cancer, including imaging
guidance for targeted prostate biopsy.

Click here to see the original abstract file
Near Infrared Radiation in Diagnosis of Prostate Cancer: Preliminary
Results

Introduction and Objectives: The goal of the present study was to
investigate the possibility of usage of near infrared radiation (NIR) in
the diagnosis of prostate cancer. Our current effort aims at developing
in vivo simple and cost-effective technology for visualization of
prostate cancer outgrowth at its early stage of development using NIR.

Materials and Methods: We present 10 cases in which radical
prostatectomy was performed. The pre-operative diagnosis of prostate
cancer was based on DRE, PSA, TRUS-B, bone scan and pelvic CT. Pathology
T1N0M0 was revealed in 4 cases, T2aN0M0 in 3 cases, and T2bN0M0 in 3
cases. After radical prostatectomy, the whole prostate was investigated
in near infrared radiation (NIR) and was compared to the respective
pathology reports. Prostates removed after the surgery were radiated
with 40 mw light emitted diode (LED) with the wavelength 850 nm- beyond
of the visible spectrum. Investigated material was placed between LED
and CCD camera in darkness, to avoid influence of any optical noise. The
images were obtained via a charge-coupled device (CCD) camera with the
resolution of up to 2 MP sensors and with the frame rates of up to 15
frames per second. CCD camera was connected to PC via USP port. The
images were then compared to the focused histopathological study.

Results: We have investigated penetration of NIR through the prostate
tissue. It was shown that NIR of 850 nm has highest penetration.
Infrared image of noncancerous prostate represents picture with
approximately even brightness. However obtained near-infrared images of
the cancerous outgrowths of the prostate revealed dense and dark foci,
which proved to be malignancy on pathology (adenocarcinoma, Gleason
score 6[3+3] in 7 cases and adenocarcinoma, Gleason score 7[3+4] in 3
cases). At brighter areas the pathology report did not reveal the
presence of malignant cells. Obtained IR images give opportunity to
distinguish prostate cancerous outgrowth with the dimensions of several
millimeter.

Conclusion: In all cases, suspected areas on NIR images were confirmed
as malignancy on pathology. These findings are expected to have impact
on more accurate diagnosis of prostate cancer, including imaging
guidance for targeted prostate biopsy.

Click here to see the original abstract file
Code of conduct/disclaimer available in General Terms & Conditions

By clicking “Accept Terms & all Cookies” or by continuing to browse, you agree to the storing of third-party cookies on your device to enhance your user experience and agree to the user terms and conditions of this learning management system (LMS).

Cookie Settings
Accept Terms & all Cookies